1) Bit of a spin on invisible walls: You can travel beyond the borders and limits of the in-game map to The Big Nothing, a volatile area of the wasteland where no food or water is present and consumed by dangerous sandstorms. If you can survive a few seconds in the area you'll sometimes find some rare parts for your car.
2) Within the Wasteland you'll need food and water to replenish Max's health and both are scarce. Avalanche point out to try looking in the sky for circling birds, this usually means there could be something dead and decomposing they're flying over which means...maggots. They're a good source of protein for Max and you can consume rodents for health too.
3) While food and water are scarce fuel isn't. From Emil Krafting, senior game designer: "We want resources to be scarce, but we also want a car game, we want to drive a lot and so on. So gas can’t be super scarce, because otherwise it would be a walking game instead of a driving game,”.
4) On foot hand to hand combat still feels like the Batman: Arkham games. Rhythmic button presses, counter-attacks, and being able to roll or dodge attacks.
5) You have access to your Garage from the pause menu allowing you to upgrade your car on the fly. The original plan was to have Garages scattered across the Wasteland but Avalanche felt it interfered with gameplay.
6) You meet Max's companion, Chumbucket, fairly early in the game and rides along with you in the Magnum Opus wielding a harpoon gun. He can use the harpoon gun to rip off tires and other parts on enemy vehicles, pull enemies out of the drivers seat and even use to impale enemies on foot.